USP <1216> friability is the rotating-drum abrasion test for uncoated tablets: a 6.5 g sample tumbles 100 revolutions at 25 rpm and must lose ≤1.0% mass. Friability failure on a supplement compress is the leading indicator of bottle-to-consumer chipping and explains complaint clusters about 'crumbled tablets' before the customer complaint file fills up.

Regulatory anchors

USP <1216>

How V5 handles it

QMS — quality engineered into every action, not bolted on.

Because V5 owns the operator action, the QMS sees the data the second it’s captured — not at the end of the shift.

Document control with hard kiosk-level training enforcement.

Versioned SOPs are only useful if operators are actually trained on the current version. V5 enforces it at the kiosk.

Related terms

Weight variation USP <2091>