Manufacturing

Decay Correction

TL;DR

The arithmetic of restating measured activity to the activity at a reference time — calibration time, administration time, or expiry. Built on A(t) = A₀ · e^(−λt).

Every radiopharma dispense is recorded with both a measured activity and a reference time. Decay correction restates that activity to whatever timepoint matters — typically Activity at Calibration Time (ACT) for shipping and Activity at Administration Time (AAT) for clinical use.

The formula: A(t) = A₀ · e^(−λt), where λ = ln(2)/t½. For F-18 (t½ ≈ 110 min) a 60-minute drive halves the dose; for Tc-99m (t½ ≈ 6 h) the same drive loses about 11%. V5 calculates decay correction live at every dispense and prints the calibration time on every dose label.

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