V5 Ultimate
Lab

Loss on ignition (LOI) — botanicals & minerals

TL;DR

Loss on Ignition (LOI), per USP <281> total ash and AOAC equivalents, is the gravimetric ash test that confirms mineral purity (calcium carbonate, magnesium oxide, dicalcium phosphate) and botanical filth limits (total ash, acid-insoluble ash). A botanical with acid-insoluble ...

Loss on Ignition (LOI), per USP <281> total ash and AOAC equivalents, is the gravimetric ash test that confirms mineral purity (calcium carbonate, magnesium oxide, dicalcium phosphate) and botanical filth limits (total ash, acid-insoluble ash). A botanical with acid-insoluble ash above the USP/EP monograph limit indicates soil/sand contamination and fails identity-plus-purity even if HPTLC confirms species.

Regulatory anchors
  • USP <281>
  • USP <561>
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