NASC

The National Animal Supplement Council (NASC) operates the dominant US industry self-regulatory programme for companion-animal supplements in absence of a DSHEA-equivalent regulatory category. The NASC Quality Seal is recognised by major pet retailers (Petco, PetSmart, Chewy, Amazon pet supplement category), veterinary distribution channels and state feed control officials as the credible evidence of legitimate quality posture aligned with FDA-CVM enforcement discretion expectations. Member companies must pass an independent third-party facility audit covering quality systems aligned with 21 CFR 111 supplement cGMP principles adapted for companion animals, ingredient supplier qualification with AAFCO/CVM compliance verification, finished-product testing per the NASC Quality Assurance Program (identity, potency, contaminants), adverse event reporting via the NASC NAERS (National Animal Adverse Event Reporting System) database, and ongoing surveillance with random product testing. The Quality Seal license is renewed annually contingent on audit and reporting compliance. Loss of the seal — through audit failure or AERS reporting failure — removes the brand from major retail and distribution channels. The NASC framework operates alongside FDA-CVM jurisdiction (animal feed under FFDCA, animal drugs under NADA), AAFCO ingredient definitions adopted by state feed control officials, and species-specific toxicology controls (xylitol absolute exclusion from dog products, allium and theobromine exclusion, lily species exclusion from cat products, essential oil restrictions for cats due to deficient glucuronidation).