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Carr's index & Hausner ratio

In short

Carr's compressibility index ((tapped − bulk)/tapped × 100) and Hausner ratio (tapped/bulk) translate USP <616> density data into a powder flow class: Carr's <15 / Hausner <1.18 = free flowing; 15–20 / 1.19–1.25 = good; 21–25 / 1.26–1.34 = fair; >25 / >1.34 = poor and a glidant or wet granulation is needed. Most supplement weight-variation rejects trace to a blend whose Hausner ratio drifted above 1.34 after a raw-material lot change.

Regulatory anchors

USP <1174>

How V5 handles it

QMS — quality records next to the work they concern.

Deviations, corrective actions and quality review sit in the same system as production, so each quality record references the work order, step and lot it concerns.

Document control — one version in force, every change signed and explained.

Draft the next revision while the current one stays in use, approve it under your sign-off route, and track training on it — with the history kept.

Related terms

Bulk & tapped density (USP <616>)

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